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	<title>Comments on: Episode 1: A ScreenCast Tutorial On How-To Do A Multiple Sequence Alignment &amp; Draw A Phylogenetic Tree Using Swami</title>
	<atom:link href="http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/feed/" rel="self" type="application/rss+xml" />
	<link>http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/</link>
	<description>Beyond bones &#38; stones</description>
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		<title>By: Luis</title>
		<link>http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/#comment-11757</link>
		<dc:creator>Luis</dc:creator>
		<pubDate>Wed, 16 Jul 2008 01:34:22 +0000</pubDate>
		<guid isPermaLink="false">http://anthropologynet.wordpress.com/?p=996#comment-11757</guid>
		<description>Erratum:

I just wrote &lt;i&gt;... would be less than 50% more distant...&lt;/i&gt;

Actually I forgot to measure the smaller segment. It&#039;s more like 55, maybe 60%. 

But the head scratching remains.</description>
		<content:encoded><![CDATA[<p>Erratum:</p>
<p>I just wrote <i>&#8230; would be less than 50% more distant&#8230;</i></p>
<p>Actually I forgot to measure the smaller segment. It&#8217;s more like 55, maybe 60%. </p>
<p>But the head scratching remains.</p>
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		<title>By: Luis</title>
		<link>http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/#comment-11756</link>
		<dc:creator>Luis</dc:creator>
		<pubDate>Wed, 16 Jul 2008 01:30:11 +0000</pubDate>
		<guid isPermaLink="false">http://anthropologynet.wordpress.com/?p=996#comment-11756</guid>
		<description>Looking in more detail, it looks like chimpanzees (or at least the dot representing them) would be less than 50% more distant from us than N-1. That is even more intriguing. 

It seems to mean that, if 2+2=4 and that program works fine (and there are no errors in the sequences), N-1 is almost as distant from us as chimps, what goes against everything we think we know about Homo sp. and specially about our close cousins the Neanderthals. 

It makes little sense. I&#039;d check for any posible input error first of all. 

If there are no such errors... then is it a discovery or just a misunderstanding?</description>
		<content:encoded><![CDATA[<p>Looking in more detail, it looks like chimpanzees (or at least the dot representing them) would be less than 50% more distant from us than N-1. That is even more intriguing. </p>
<p>It seems to mean that, if 2+2=4 and that program works fine (and there are no errors in the sequences), N-1 is almost as distant from us as chimps, what goes against everything we think we know about Homo sp. and specially about our close cousins the Neanderthals. </p>
<p>It makes little sense. I&#8217;d check for any posible input error first of all. </p>
<p>If there are no such errors&#8230; then is it a discovery or just a misunderstanding?</p>
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	<item>
		<title>By: Luis</title>
		<link>http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/#comment-11755</link>
		<dc:creator>Luis</dc:creator>
		<pubDate>Wed, 16 Jul 2008 01:14:54 +0000</pubDate>
		<guid isPermaLink="false">http://anthropologynet.wordpress.com/?p=996#comment-11755</guid>
		<description>Glad to be of some use. It looked strange, just that. 

&lt;i&gt;The gorilla is now slightly more closer than the orangutan, but Neandertal-1 now is more dissimilar than Neandertal-2.&lt;/i&gt;

That&#039;s pretty interesting. I wonder if that means something or is just &quot;noise&quot; introduced by the small sample. I can just assume that humans, chimps, etc. are not just points either but that they are distributed by some small range. Still the distance between both neanders seems pretty large. N-1 is almost twice as distant from the split with sapiens as his cousin N-2. 

It looks as if they had a large genetic diversity and also as if N-2 would be more &quot;archaic&quot; and N-1 more &quot;evolved&quot;. Are they from very different dates? Or maybe geographies? (I think I know which are the two specimens but too tired to search for them now). 

It cannot mean hybridation in any case, because that would not affect the mtDNA at all.</description>
		<content:encoded><![CDATA[<p>Glad to be of some use. It looked strange, just that. </p>
<p><i>The gorilla is now slightly more closer than the orangutan, but Neandertal-1 now is more dissimilar than Neandertal-2.</i></p>
<p>That&#8217;s pretty interesting. I wonder if that means something or is just &#8220;noise&#8221; introduced by the small sample. I can just assume that humans, chimps, etc. are not just points either but that they are distributed by some small range. Still the distance between both neanders seems pretty large. N-1 is almost twice as distant from the split with sapiens as his cousin N-2. </p>
<p>It looks as if they had a large genetic diversity and also as if N-2 would be more &#8220;archaic&#8221; and N-1 more &#8220;evolved&#8221;. Are they from very different dates? Or maybe geographies? (I think I know which are the two specimens but too tired to search for them now). </p>
<p>It cannot mean hybridation in any case, because that would not affect the mtDNA at all.</p>
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	<item>
		<title>By: Kambiz Kamrani</title>
		<link>http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/#comment-11726</link>
		<dc:creator>Kambiz Kamrani</dc:creator>
		<pubDate>Mon, 14 Jul 2008 14:36:51 +0000</pubDate>
		<guid isPermaLink="false">http://anthropologynet.wordpress.com/?p=996#comment-11726</guid>
		<description>Hi Luis,

Thanks for you comment. You raise some valid points that I overlooked, I&#039;ve taken out the &#039;extra&#039; sequences in the orangutan sample and updated the sample sequences as well as the image. The gorilla is now slightly more closer than the orangutan, but Neandertal-1 now is more dissimilar than Neandertal-2. 

Kambiz</description>
		<content:encoded><![CDATA[<p>Hi Luis,</p>
<p>Thanks for you comment. You raise some valid points that I overlooked, I&#8217;ve taken out the &#8216;extra&#8217; sequences in the orangutan sample and updated the sample sequences as well as the image. The gorilla is now slightly more closer than the orangutan, but Neandertal-1 now is more dissimilar than Neandertal-2. </p>
<p>Kambiz</p>
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		<title>By: Luis</title>
		<link>http://anthropology.net/2008/07/13/episode-1-a-screencast-tutorial-on-how-to-do-a-multiple-sequence-alignment-draw-a-phylogenetic-tree-using-swami/#comment-11725</link>
		<dc:creator>Luis</dc:creator>
		<pubDate>Mon, 14 Jul 2008 11:41:30 +0000</pubDate>
		<guid isPermaLink="false">http://anthropologynet.wordpress.com/?p=996#comment-11725</guid>
		<description>Hmmm... I&#039;m not any expert in this bioinformatic tech but I find quite odd that gorillas look more distant than orangutans in that NJ tree (normally gorilla would be closer to chimp and human than to orangutan). I also find odd that the orangutan&#039;s sequence is more than twice as long as any of the others and I wonder if that may have introduced errors.</description>
		<content:encoded><![CDATA[<p>Hmmm&#8230; I&#8217;m not any expert in this bioinformatic tech but I find quite odd that gorillas look more distant than orangutans in that NJ tree (normally gorilla would be closer to chimp and human than to orangutan). I also find odd that the orangutan&#8217;s sequence is more than twice as long as any of the others and I wonder if that may have introduced errors.</p>
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