Pinpointing The Geographic Origins Of Europeans From Their DNA
Last month, I read and reviewed two papers that correlated the genetic and linguistic structure of European populations to their geographic locations. A new paper came out several days ago in Nature which announces a new model where the genetics of 3,200 Europeans is used to predict their country of origin, with an accuracy of a few hundred kilometers.
The paper, “Genes mirror geography within Europe,” comes from John Novembre and crew. They got their data from GlaxoSmithKline. 500,000 SNPs were compared and when they were plotted after two principle component analyses, the authors were able to see distinct clustering of geographically distinct populations. This is the image they provided.
Genetic & Geographic Separation of European Populations
Placing a map under this distribution shows how distinct the Iberian peninsula is from the Italian peninsula and within the ‘mixing pot’ French, German and Italian-speaking Swiss individuals are genetically separated. To touch on the accuracy issue again, with countries that had more individuals represented in the sample, this new method could pinpoint their origins to 310 kilometers. On average, the accuracy was able to identify an individual’s origins to 540km.
As P-ter of Gene Expression points out, the biggest restriction to this study is the array of SNPs on the GeneChip and the number of individuals sampled. With higher resolution GeneChips, ideally full genomes, and larger samples, we’ll be able see much more accurate genetic-geographic separations of populations.
- John Novembre, Toby Johnson, Katarzyna Bryc, Zoltán Kutalik, Adam R. Boyko, Adam Auton, Amit Indap, Karen S. King, Sven Bergmann, Matthew R. Nelson, Matthew Stephens, Carlos D. Bustamante (2008). Genes mirror geography within Europe Nature DOI: 10.1038/nature07331
[...] and patterns are emerging. We’re now able to isolate distinguishable genetic differences in places like Europe. In the past, I’ve argued that with these higher resolution and more ubiqutious technologies [...]
Mark Stoneking’s Four Models Of Human Origins « Anthropology.net
September 19, 2008 at 8:27 am
[...] of studies will continue to discover and refine the methods and findings. As Kambiz stated at Anthropology.net, "With higher resolution GeneChips, ideally full genomes, and larger samples, we’ll be [...]
Ancestral GPS - Pinpointing the Geographic Origin of Autosomal DNA Sequences » The Genetic Genealogist
September 24, 2008 at 1:07 pm
The large assay of SNPs from Europeans just shows that the origins of Europeans, other than simply looking at their external appearance, can be traced using SNPs provided the list of SNPs is large enough.
What I want to know as a European is not where I come from, I know that already, but where do Europeans originate. All Europeans are from somewhere else, i.e immigrants, the difference is when they arrived in Europe. Where did the East European types come from? Where the classic Nordid Europeans? Where the thicker set Central and North Europeans? Most people accept that Southern Europeans are directly from the Middle East from Neolithic times but the rest of Europeans, no one knows.
Ponto
April 22, 2009 at 3:53 am