Comments on: Genetics of High Altitude Life http://anthropology.net/2010/05/16/genetics-of-high-altitude-life/ Beyond bones & stones Sun, 27 May 2012 23:21:41 +0000 hourly 1 http://wordpress.com/ By: ProfdoC http://anthropology.net/2010/05/16/genetics-of-high-altitude-life/#comment-23679 Wed, 27 Apr 2011 21:53:02 +0000 http://anthropology.net/?p=3251#comment-23679 Interesting, however only EGLN1 AND EPAS1 have been consecutively found in genome wide scans, and are associated with hemoglobin levels, and with altitude, higher fequency of haplotype variants with altitude. This study that did not find EPAS1, read Xu et al, 2010/11 it describes this. The link to Hb may provide a functional variant that lowers Hb, which studies such as Gustavo et al., 2009 say are linekd to better outcoems in pregancy. I for one believe that EPAS1 has EGLN1 have hidden effects in utero during pregnancy that may protect birth weight at alitude, remember ancestry protects bbirth weight at alittude, Tibetans have less IUGR than andeans who have less than han who have less than europeans. I for one think EPAS1 is linked to less repiratory distress and ease of first breath in Tibetan infants, due state of surfacant, HIF2a related to vegf and surfucant, knockout hif2a less surfucant and vegf, exogenous vegf gives surfucant. Nieymeyer et al., 2004 decribes this, persisten fetal ciruclations whcih would likely effect o2 saturation first 4 months and HPV. Also may have affect on nitric oxide levels, fucntional assays have to be done. and retrospective or prospective studies linking genes to these variables.

Interesting also that PEAS1 may have role in retinopathy, due to its role angiogensis retinal devlopment, may protect in alititude. UC related blindness.

]]> By: Noura Howell http://anthropology.net/2010/05/16/genetics-of-high-altitude-life/#comment-17780 Thu, 15 Jul 2010 07:20:49 +0000 http://anthropology.net/?p=3251#comment-17780 What is your source on UV increasing by 4% for every 1000 foot of altitude? I am trying to find information on the solar spectrum at high altitudes.

If you could email me where you found this info, I would really appreciate it.

]]> By: Henry Lahore http://anthropology.net/2010/05/16/genetics-of-high-altitude-life/#comment-17442 Sat, 22 May 2010 15:48:13 +0000 http://anthropology.net/?p=3251#comment-17442 More UV and vitamin D at high altitude as well.
UV increased by 4% for every 1000 foot of altitude
See the health benefits of UV and vitamin D at VitaminDWiki

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