Ultraselected & Ultraconserved Regions of the Human Genome

This Science paper just came out from my alma mater, UCSC, and it should be a very interesting read:

Human Genome Ultraconserved Elements Are Ultraselected

Ultraconserved elements in the human genome are defined as stretches of at least 200 base pairs of DNA that match identically with corresponding regions in the mouse and rat genomes. Most ultraconserved elements are noncoding and have been evolutionarily conserved since mammal and bird ancestors diverged over 300 million years ago. The reason for this extreme conservation remains a mystery. It has been speculated that they are mutational cold spots or regions where every site is under weak but still detectable negative selection. However, analysis of the derived allele frequency spectrum shows that these regions are in fact under negative selection that is much stronger than that in protein coding genes.

Oh yes, this new transposon piece is also intriguing. I guess I gots reading to do.

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