Are sisters more genetically similar than other siblings?

People often ask whether biological sisters from the same parents are more closely related than a brother and sister? Why do they ask this? Because, sisters get the same X chromosome from their father. Ken Weiss, professor of anthropology and genetics at Penn State answered that question, stating that sister-sisters siblings are more genetically similar than brother and sister sets.

“Weiss offered a lesson in basic biology: Get a piece of paper and a pen. Draw a circle for the mother and a square for the father. Populate the circle with “XX” for the female sex chromosome and the square with “XY” for the male chromosome. Draw two more circles under the symbols for the parents to represent two sisters.

“The two daughters below them are going to inherit an X from their mother, one or the other. Each one gets an independent choice,” said Weiss. “But if they’re daughters, they have to be XX, which means they must both inherit the same X from their father, since he only has one to give them. Everything else is scrambled equally between the two sisters from the two parents. They have one X that they share, and one X that they may or may not share, depending on the luck of the draw from the mother.”

Now, if you were to draw two squares for brothers under the parents, you would pull one or the other X from the mother and the Y from the father, because to be a son you must be XY and the Y can only come from Dad.

Humans have 46 chromosomes, inheriting 22 non-sex chromosomes, and one sex chromosome, from each parent. What they inherit from the other chromosomes is similar regardless of sex, which overall makes the child 50 percent related to each other and to each parent. In this sense, Weiss said, “Two brothers are as equally close to each other as two sisters. A brother and a sister are not as closely related as two brothers or two sisters. They’re a bit more distantly related.” This is because one will have an X and the other a Y from their father, whereas two brothers must share the same Y, and two sisters the same X, from him.”

I don’t know of Weiss has published this ‘finding’ of his in any peer-reviewed journal. The press release the Penn State is running doesn’t mention it anywhere but it would be an interesting study if applied. Has anyone seen this make the rounds in the journals?

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