Foxp2(hum) Increases the Length of Dendritic Trees

(A) Foxp2hum/hum and Foxp2wt/wt striatal neurons stained for the neuronal marker betaIII-tubulin (green) after 7days of differentiation. Plotted are averages (SEM) of three individuals for each of which the total neurite length of five neurons was measured. Asterisks indicate a significant difference (Mann-Whitney U, p < 0.01) between the 15neurons of each genotype.
(B) Golgi-Cox staining and representative drawings of medium spiny neurons invivo. Plotted are averages (SEM) of six (nine for Foxp2wt/wt) individuals for each genotype of which the total dendritic tree of three neurons has been measured. Asterisks indicate a significant difference (Mann-Whitney U, p < 0.05) between the neurons of each genotype. Scale bars represent 25 m.

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