Grandma Plays Favourites: X-Chromosome Relatedness and Sex-specific Childhood Mortality – Proceedings of the Royal Society B

As this paper is freely accessible for the next 7 days, I’m posting it here in the hope that as many readers as possible will have time to readgrandmother hypothesis primate diaries it through. Molly Fox et al turn their thoughts to the question of why women are able to live for many years after they able to conceive offspring, a phenomenon seemingly at odds with the idea that members of a species tend to die off once their reproductive days are over.

The ‘Grandmother Hypothesis’ is described and expanded upon thus in the linked paper:

With menopause occurring around age 50, women survive several decades longer than their gametes (Dorland et al. 1998; Hawkes 2003). Why should women have such conservative life histories that they save up enough energy for 25 years of reproductive retirement? Human females represent a particular conundrum in evolutionary studies: after menopause they are unable to reproduce and have no obvious way to increase their genetic contribution to future generations. As this is the basis for natural selection, many researchers have sought to explain how post-menopausal longevity is adaptive in women.

Among evolutionary biologists, the ‘grandmother hypothesis’ is the most widely recognized explanation for human female post-reproductive longevity. It suggests that vigorous, skilled, elderly women are able to contribute to their grandchildren’s survivorship through nutritional provisioning (Hawkes et al. 1998; Hawkes 2003). According to Hamilton’s relatedness coefficients (Hamilton 1966), grandmothers share a quarter of their DNA with grandchildren, and so a woman can increase her genetic contribution to subsequent generations by keeping her grandchildren alive and healthy. Supporters of this model often refer to the Hadza, a modern foraging society in Tanzania, where grandmothers are more effective than children at extracting tubers from the dry ground. While a mother is breastfeeding an infant, and thus unable to forage enough to provide for weaned children, the grandmother provides food for the older siblings (Hawkes 2003; Hawkes & Jones 2005).

The authors further suggest that this may be a behavioural and survival trait that can trace its roots back to the early Pleistocene, 1.7m-1.9m years bp (described in the paper as the Plio-Pleistocence boundary, recently re-dated to 2.6m years bp), when global cooling caused the expansion of African tuber-friendly grasslands, prompting ancient hominids to include a great many more tubers in their diet. From these origins, where grandmothers are suggested to have been important contributors of nutrition to two generations of descendants, researchers such as Soffer and Adovasio have taken the theory further, suggesting that grandmothers contributed a much greater role in child-rearing than simply providing nutritional foodstuffs.

The interesting aspect of this paper is how the authors suggest simply having a grandmother isn’t equally beneficial to grandchildren of either gender, with clear differences suggesting that in some instances having a maternal grandmother can be better for boys than a paternal grandmother, whilst a grand-daughter with a maternal grandmother appears to benefit most of all, as indicated here:

Tests of the grandmother hypothesis have been carried out on modern and historical populations. Most of the data correlate grandchild survivorship with grandmother survival and/or proximity, and it is often reported that only maternal grandmothers (MGMs) are found to have a positive effect on grandchild survivorship (Sear et al. 2002; Voland & Beise 2002). Studies that have not distinguished between MGMs and paternal grandmothers (PGMs) have found no correlation between grandmother’s presence and grandchild survivorship (Hill & Hurtado 1991; Lahdenperä et al. 2004). To date, only two previous studies known to the authors have distinguished between boys and girls when investigating the effect of both grandmothers.

A study of a Japanese population found that the presence of a PGM had a negative effect on boys and a positive effect on girls, while the presence of an MGM had a positive effect on children of both sexes, especially on boys (Jamison et al. 2002). They point to cultural features of the society as a possible mechanism for these findings. A study of an Ethiopian population reported the sex-specific information, but it was not analysed in the paper (Gibson & Mace 2005). More tests of the grandmother hypothesis are summarized in Sear & Mace (2007).

The authors continue by proposing the following:

The grandmother hypothesis is based on the fact that women are genetically related to their grandchildren, and we should not overlook the nature of that genetic relatedness. Grandsons and granddaughters differ in the proportion of their X-chromosomes shared with MGMs and PGMs (figure 1). According to our proposed X-linked grandmother hypothesis, if grandmothers invest in grandchildren because of their genetic relatedness with them, then their adaptive incentive to invest may vary in a way that mirrors this variation in genetic relatedness. As a consequence, grandmothers’ differential investment in grandchildren could cause differential survivorship of those grandchildren…

…Although the X-chromosome contains only about 4.4 per cent of our DNA, with its estimated 1529 genes, it contains perhaps approximately 8 per cent of all human genes (Pennisi 2003; NIH 2007; Parang et al. 2008; NCBI 2009a). The dramatic differences in X-relatedness between grandmothers and grandchildren confound the Hamiltonian concept that grandchildren are 25 per cent genetically related to each grandparent. If approximately 92 per cent of our genes are autosomes, then a grandmother shares one-quarter of that, or approximately 23 per cent of her total genes with a grandchild, plus X-relatedness.1

If a grandmother shares no X-chromosome with a grandchild, then their overall genetic relatedness is approximately 23 per cent, and if they share an entire X-chromosome, then it would be approximately 31 per cent. Therefore, MGMs and grandchildren are likely to share 25 per cent of their genomes, while PGM and granddaughter may share a total of approximately 31 per cent of their genes, with a likelihood of 27 per cent inheritance, while a PGM and grandson may share only approximately 23 per cent.

We can only wonder whether these conclusions were borne out in ancient communities and whether it was realised that there was closer bonding and greater survival amongst children with certain alloparental configurations, or whether child-care was undertaken on a more ad hoc basis, whereby other surrogate mothers who were still of reproductive age were also co-opted into rearing off-spring when the need arose. Moreover, infant mortality was probably high and seemingly arbitrary, especially where actions of predators, illness and infections were concerned, in which case the grandmother effect would have been diminished, except in those cases where an older person such as a grandmother would have had greater experience in recognising symptoms and knowing of potential remedies, something which presumably could also have applied also to grandfathers.

I’m not sure at what age humans living in the early and later stages of the Pleistocene would have become grandparents, but my guess would be quite young, possibly by age 30-35, though whether females would also have become unable to conceive by that age I don’t know; but it seems there could have been some overlap, during which time a grandmother could herself have still given birth to children, unless a menopausal clock kicked in soon after their own off-spring had given birth, which seems unlikely. If we still assume an age of 50 for menopause however, by the time she reached 50, a Pleistocene woman could easily find herself in the role of great-grandmother, though whether humans in significant numbers reached that ripe old age back then, again seems unlikely.

This latest study studies more modern humans rather than our Palaeolithic counterparts, as explained by Michael Balter at Science NOW:

Knapp and her co-workers looked at the survival of grandchildren in seven modern-day and historical societies for which good family records were kept. The societies included rural farming villages in Japan, Ethiopia, Gambia, and Malawi, as well as towns in Germany, England, and Canada going back as far as the late 1600s, whose data were gleaned from church and other historical records. When the data from all seven populations were combined in one meta-analysis, there was a highly significant correlation between the degree of relatedness of grandmothers living with or near a family and the survival rate of their grandchildren, the team reports online today in the Proceedings of the Royal Society B. Thus paternal grandmothers were most beneficial to the survival of their granddaughters and least beneficial to the survival of their grandsons, while maternal grandmothers showed an intermediate effectiveness.

Experts are thrilled by the findings. “Wow, very interesting,” says Hawkes. “The consistent results across seven populations … seem to clarify previously inconsistent results.” Lorena Madrigal, an anthropologist at the University of South Florida in Tampa, calls the study “an important contribution to a topic of great interest to evolutionary biologists.”

Still unanswered, however, is the exact mechanism that apparently leads grandmothers to favor some grandchildren over others. There is no evidence that they do it deliberately, the authors point out, leaving the possibility that more closely related children give off some sort of signal such as physical resemblance or a certain smell, or that grandmothers–especially on the paternal line–are passing down some sort of “genetic imprinting” that gives their grandchildren a survival advantage.

As a final point of conjecture, these studies tell us little about the role grandfathers may have played in all this – whether they continued to play an active role in their communities, or were instead consigned to life on the Palaeo scrap-heap we don’t know. It’s almost tempting to suggest that prehistoric grandfathers turned their hand to flint-knapping and related lithic activities, reminiscent of the way in which modern men of a certain age often take to spending a great deal of time in the garden shed, pottering about with who knows what, largely because they can think of absolutely nothing else to do.

Grandfathers at various stages in the Pleistocene may have found it hard to attract sexual partners of the opposite sex, been prevented from participating in hunting expeditions due to lack of fitness, or because they carried long-term injuries sustained earlier in life. Meanwhile their former mates, the grandmothers, were by necessity often occupied looking after the grand-kids when the mothers were done with breast-feeding, or out gathering tubers as exemplified by the Hadza, amongst a plethora of other activities, all of which may have left them too tired to devote much time and attention to their putatively bored and frustrated male spouses at the end of the day.

But as we know, stone technology shows little or no evidence of being gender-specific, and further, a great deal of stone tools were made on the spot after a kill had been made and immediate butchery was required, so grandfathers may have little or no input in these matters. Perhaps instead, those early grandfathers were the original grumpy old men, having too much time on their hands and too little to do with them, looking out across the savannah at the departing or returning groups of people from whom they were now set apart, saying things like “Ay, this were all trees when I were a lad, now look at it”, before being awoken from their reverie by yet another shout of “Move it Gramps, hunting party coming through.”, leaving the not-so-proud grandfathers to forlornly wander off into their sunset years, sighing at the perceived injustice of it all.

As mentioned at the top of this post, this fascinating paper is unobstructed by a paywall for 7 days as I write this, and I’m not sure for how long Michael Balter’s article will also remain online in its present form, so it might be an idea to check them out sooner rather than later.

See also: The Evolution of Menopause @ The Primate Diaries, from where the image at top is taken.

References: Grandma Plays Favourites: X-Chromosome Relatedness and Sex-specific Childhood Mortality, by  Molly Fox, Rebecca Sear, Jan Beise,, Gillian Ragsdale, Eckart Voland and Leslie A. Knapp, Published online before print October 28, 2009, doi: 10.1098/rspb.2009.1660

Grandma Plays Favorites, By Michael Balter, ScienceNOW Daily News, 28 October 2009.

 

 

 

11 thoughts on “Grandma Plays Favourites: X-Chromosome Relatedness and Sex-specific Childhood Mortality – Proceedings of the Royal Society B

  1. I am shocked by trying to attribute to genetics this variance: the sex chromosomes only account for 4.35% of the genome (taking all chromosomes as equal, what is a simplification admittedly). So even if it’s true that the grandson of a PGM does not have any of her sex chromosome data, he still has around 1/4 of her haploid genome, which makes up some 95% of the whole genome. The difference is statistically irrelevant to explain anything.

    PGM’s grandson has c. 24% of her genome (statistically: 95%/4), MGM’s grandaughter has c. 26% of her genome (95%/4+(5%/2). The difference is so ridiculous that can’t explain a thing.

    I would rather look on sociological factors like greater natural empathy of mothers for her daughter’s well doing (including her offspring). It would be logical in a sense that MGMs were the natural grandmothers, with no role (or a very secondary one at best) for PGMs. But not for any genetic reason but for mere emotional and social affinity between mother and daughter.

  2. Ok, they argue that the X chr has more genes than it would normally correspond (8%), what twists a bit the maths. But I still don’t think this makes such a huge difference.

    And I still don’t get their 31% MGM-GD affinity but just 25% when I correct the figures for that:

    100%-8%=94%

    PGM-GS: 94/4=23%
    MGM-GD: (94/4)+(8/4)=25%
    PGM-GD: (94/4)+(8/2)=27%

    Unless I’m missing something important, these are the real figures for overall relatedness. There is a difference but it is very small.

  3. “I would rather look on sociological factors like greater natural empathy of mothers for her daughter’s well doing (including her offspring)”.

    That was my first thought on reading the post and I see no reason to change my mind. And even today many children are unsure who their father is.

  4. And even today many children are unsure who their father is.

    You nailed it here: I did not even consider that the PGM would be affected by that factor but it’s obviously much more important. A MGM knows she has an investment in her daughter children, a PGM knows nothing for sure.

  5. A PGM could make a good guess, though, if her child and putative child had some unusual characteristic in common – let us say, for the sake of argument, red hair. Then both grandmas have an incentive to look after the mother and child and then redheadedness could constitute an evolutionary advantage. There you are – the carrot-top explained. Yes, now you ask, I am prepared to accept the Nobel Prize.

  6. Actually, light-heartedness apart, that is a mechanism that positively favours the development of ANY unusual characteristics, so long as they are not of themselves an evolutionary disadvantage. By gum. Good Lord, have I contributed to biological science?

  7. i think you are looking to far, productive members of the group are just tolerated, pretty soon the few woman that thus survived menopause would have a cultural niche. that in the end they doubtlessly contributed to the survival of their offsprings genes, oh well it is true, but i don’t think it is anymore specific then in other great mammals, like eg. whales that are often (seemingly at least) lead by an older female. so what i actually think is their survival rates granted them a niche automatically, and not so much that the niche granted them survival rates.

  8. “their survival rates granted them a niche automatically, and not so much that the niche granted them survival rates”.

    You might have something there. At any rate I think the survival of particular offspring is unlikely to be simply the result of genes on the X chromosome.

  9. wich i technically doubt, simply put we are all offspring of murderous victors, at least in europe. any gene that prominently expresses thus implies that exact result of survivability, i just doubt it did that much to our social structures , i expect more that genes will show to be coherent to neccesary quality’s of that surround. more of a bottom-up thing, then a top-down thing. perhaps it will be debated in eternity.

  10. i also think it will be easy to proof pgm’s function more/better for the survival of grandchildren when they are more sure. i am however quite convinced that mgm’s function more easily in that sense. for an example, woman have cells of all their children in their body’s specifically the brain,
    i think it has much a do with the natural direction of their biological empathy’s. (and thus that genes are not all-telling persee , but they are that in combination with merely physical (biological) factors). interestingly that poses the question who was first (the bird or the egg) and when exactly did genetics incorporate these biological effects, pretty well possible before we ever grew into sth. more then a primate, and possibly long before that. allthough the same matter of it’s allways an egg before a bird, interestingly we could perhaps pinpoint a few of the related genetic developments on a timescale. btw. for animals smell usually suffices to make the distinction, and it would be somewhat farfetched to assume humans would have lost all that capacity to turn into humans, altho that be kinda nice and contrary to existing theory.

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